Express duo cleared for league action

first_imgJohnny Levita in action against Wakiso Giants in preseason (file photo)WANKULUKUKU – Having missed the draw at home to URA and the 3-1 defeat away to Mbarara City due to International Transfer Certificates (ICT) issues, Express duo of Isaac Mutanga and Johnny Levita have been given the go ahead to start playing.After sorting everything out with their former side CD Bukavu Dawa of Congo, the pair is now expected to feature in Express’s next dual with Police FC when the league resumes next week.Defender Isaac Mutanga is on a return to Express after playing for the 6-time champions in the 2015-16 season. He was named assistant captain at the start of this season to deputise Julius Ntambi.Johny Levita is expected to be a mainstay in Kefa Kisala’s midfield department on the account of his impressive preseason exploits.Express who sit 13th on the log will play against Police FC at the StarTimes Stadium Lugogo in their next league game on Tuesday 16th October.Comments Tags: Express FCpolice fcStarTimes Uganda Premier Leaguelast_img read more

Nuclear pore complexes are critical for survival of circulating T cells study

first_img Source:https://www.sbpdiscovery.org/ May 8 2018Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus-;they play an essential role in the survival of T cells. A new study by Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers describes how a specific nuclear pore component is critical for the survival of circulating T cells. The findings, published in Nature Immunology, identify a new node of T cell receptor signaling and could pave the way for the development of future immunotherapies.”Our study provides the first evidence of a role for nuclear pore complexes (NPCs) in the regulation of T cell activity,” says Joana Borlido, Ph.D., postdoctoral scholar at SBP and lead author of the study. “We have identified a nuclear pore protein (Nup210) that circulating CD4+ T cells need to sense the molecular signals they require to survive. This is an unexpected discovery that may potentially be exploited for immune therapies to treat autoimmune and inflammatory disorders, infectious diseases and cancer.”NPCs are the passageways that control the hundreds of thousands of molecules that travel between a cell’s nucleus and cytoplasm. NPCs are built from 32 different proteins (nucleoporins) whose levels can vary in different cell and tissue types. Historically, NPCs were viewed as passive structures that control the trafficking of molecules-;proteins and RNA-;between the two cell compartments. But over the past decade, it’s become evident that they also play a role in regulating gene activity and cell function.”We knew that Nup210 was present in its highest levels in immune tissue, but we wanted to explore what this meant from a physiological perspective and whether it contributed to immune cell functions,” says Borlido.Related StoriesMathematical model helps quantify metastatic cell behaviorComprehensive cell atlas of the human liverAbcam Acquire Off-The-Shelf Diploid Library of Over 2,800 Knockout Cell LinesThe research team used a knockout mouse model in which the gene for Nup210 was disrupted. Deletion of Nup210 resulted in a dramatic reduction of circulating CD4+ T cells. While the development and migration of these cells occurred normally, the survival of peripheral CD4+T cells was compromised, disrupting homeostasis.”Peripheral T cell homeostasis is achieved by careful orchestration of cell survival and division,” says Maximiliano D’Angelo, Ph.D., assistant professor at SBP and senior author of the study. “This study clearly links the loss of Nup210 with deficits of mature naïve CD4+ T cells, which are the cells that enable the body to fight off infections and diseases.A healthy pool of circulating CD4+ T cells includes both naïve and memory T cells-;the cells that respond to bacteria, viruses and cancer cells previously encountered through infection or vaccination. Maintaining a balance of mature CD4+ T cells is essential for immune health. CD4+ cells secrete key molecules that trigger other immune cells to kill pathogens, make antibodies and shut down the immune system to prevent uncontrolled inflammation and autoimmune disorders. If you don’t have these cells you can’t fight infections and you are at risk of many diseases, including cancer.”Our next step is to investigate how Nup210 promotes pro-survival functions, which could be especially important for modulating the numbers and function of T cells in immune-based therapies and autoimmune disorders” says D’Angelo.​​last_img read more