Newsstand Declines Hitting New Lows Across More Categories

first_img There’s more bad news in the analysis of who’s being affected by the consumer’s growing lack of interest in picking up single copies. MagNet data shows that smaller titles whose newsstand sales had been holding up well against bigger ones are now feeling the squeeze. Whereas the top 25 and 50 titles had been experiencing larger declines, the latest data show that titles in the top 100 and top 1000 have pulled even. The percentage decline in sales is now more similar across all groups of titles through the top 1000, ranging from -1.4 percent for the top 25, to 3.2 percent for the top 1000. MagNet, though, puts a caveat on the comparison; the 2014 numbers may be overestimated both because numbers from Source Interlink Distribution dried up when it went out of business, and Barnes & Noble stopped providing data this year. That even despite publishers responding by paring back the number of hard copies distributed by 40 million over the same time period, but perhaps owing partly to an average 5 percent increase in cover prices. The latter move was factored into a dollar sales efficiency figure of 26.5 percent.  Yet MagNet is confident enough in the numbers to suggest in its narrative on the data that a stabilization of newsstand circ doesn’t appear to be in sight. The decline began eight years ago and sales are approaching an inauspicious milestone. The newsstand tracker’s first-half 2015 numbers are in and they show that the key metric of sales efficiency hit what it says is an all-time low. Only 26.8 percent of the magazines publishers distributed to retail outlets actually sold, down from 31 percent in the first half of 2014. Newsstand performance comparison for U.S. and Canada, first half 2015 versus 2014. (Includes estimates for Barnes & Noble sales) Source: MagNetcenter_img “We estimate that newsstand magazine sales will generate about $2.5 billion in 2015, just about half of what was generated in 2007,” the review reads in part. It’s getting to be old news now. Magazine newsstand sales are declining, according to the latest data from MagNet. But what is new, and worrisome, is that the declines are accelerating and the pain is spreading. MagNet’s outlook for 2015 looks even gloomier looking beyond the first-half numbers that are in the books. It says preliminary July and August numbers are tracking worse than those for the first half. Title rank comparison for U.S. and Canada, first half 2015 versus 2014. (Data does not include Barnes & Noble sales) Source: MagNetlast_img read more

Article 13 EU countries approve copyright directive

first_img Share your voice Internet Services Tech Industry Tags The EU has adopted Article 13, among other reforms. Jaap Arriens/NurPhoto via Getty Images European countries approved sweeping reforms to copyright law on Monday after the European Parliament voted to adopt the new legislation last month.The EU Copyright Directive will protect and govern how copyrighted content posted online, bringing outdated rules up to scratch for the internet age. The law has been hotly debated both by politicians and the wider tech community, with some of the world’s biggest companies taking a strong stance against the legislation — in particular a section known as Article 13.Article 13 dictates that anyone sharing copyrighted content must get permission from rights owners — or at least have made the best possible effort to get permission — before doing so. In order to do this, it’s thought that internet services and social networks will have no choice but to build and enforce upload filters and generally apply a more heavy-handed approach to moderating what users post online.For proponents of digital rights, the approval of the directive comes as a huge blow after over a year of campaigning to uphold what they see as the integrity of the internet. Following the European Parliament vote in March, there was hope that enough key countries might try to block the directive that it wouldn’t pass, but ultimately it didn’t face enough opposition on a national level (all EU legislation faces a final vote by member states before it can pass into law).Italy, Luxembourg, Netherlands, Poland, Finland and Sweden voted against adopting the directive, whereas Belgium, Estonia and Slovenia abstained. In total 19 countries voted to approve the legislation.”This is a deeply disappointing result which will have a far-reaching and negative impact on freedom of speech and expression online,” said Catherine Stihler, chief executive of rights group the Open Knowledge Foundation in a statement. “The controversial crackdown was not universally supported, and I applaud those national governments which took a stand and voted against it.”But not every was disappointed by Monday’s result. A coalition of organizations representing news publishers in Europe celebrated the adoption of the directive. “This important reform will help make the EU copyright regime fit for the digital age without stifling digital innovation,” said Christian Van Thillo, chairman of the European Publishers Council in a statement.center_img 2 Commentslast_img read more

Paul McCartney almost played Ross fatherinLaw on Friends

first_imgBeatle star Paul McCartney almost guest starred on Friends as he was offered the role of Ross’ father-in-law.Emmy-nominated casting director Leslie Litt, who was working on the NBC hit series during most of its run, revealed that McCartney, now 72, could’ve appeared in the season 4 finale of the show as David Schwimmer’s on-screen father-in-law, but he turned it down, reported Huffington Post.“I went through his manager and gave him all the details. One day, someone in the office brought me a faxed letter written to me by Paul himself! He thanked me for my interest and said how flattered he was, but it was a very busy time for him,” Litt said.If the British musician had agreed to do it, he would’ve appeared in the two-part season four finale which aired in 1998.In the said outing, Ross married Emily (Helen Baxendale) in London though he accidentally said Rachel’s (Jennifer Aniston) name instead of his bride’s name at the altar.last_img read more

Promoting and preserving public art

first_imgFifteen artists from different backgrounds have gathered to showcase sculptures and installations on the theme of ‘Public art and its relevance’, at India International Centre. Titled ‘Sculpt for Delhi-II’, the group exhibition was inaugurated by Anil Baijal, Lt Governor, Delhi and Ambassador of Bulgaria Eleonora Dimitrova in the presence of Vijay Kumar Dev, Chief Secretary, Delhi.”Exhibitions like these offer a platform to express our thoughts through the medium of art, showcase our creativity, and bring it into the notice of concerned authorities. The authorities need to understand our strengths, and therefore use our potential in the best way possible. It is a way to communicate with them and discuss the importance of such installations and sculptures for artists as well as the public,” said Shovin Bhattacharjee, whose sculpture ‘Mystery of life’ highlights how urbanisation is destroying the nature. Also Read – Add new books to your shelf”I have tried to bring a mirror in front of the people to see the sad reality, and understand why it’s important to be sensitive towards nature,” he added. The show is conceptualised by artist and sculptor Neeraj Gupta, President, Delhi Art Society in collaboration with Indian International Centre, and will go on until March 19. Well-known artists including Bipasa Sen Gupta, Anjali Khosa Kaul, Asurvedh, Suresh Kumar, O P Khare, Sangeeta Gupta, Farhat Jamshed, Neeraj Gupta, Shreedhar Mukul Panwar, Kavita Nayyar, among others, have created tangible forms and figures of smooth stimulations, gradual escalation of symmetry and a hint of mystery for the ongoing exhibition. Also Read – Over 2 hours screen time daily will make your kids impulsiveOn this occasion, Lieutenant Governor of Delhi, Anil Baijal said that this exhibition will be a witness to the symbol of art and cultural influences, which the artists have raised with finesse. All artists have given their best to make this exhibition one of its kind. I have always been a fan of sculpture exhibitions, and I congratulate the Delhi Art Society and India International Centre for organising such an event with great enthusiasm.” Neeraj Gupta said, “This liberating form of art is a mystical practice, and thus brings together a dreamy amalgamation of form, features, ideations, and ideals. Art is what metamorphoses the world into a more humane world. ‘Sculpt for Delhi II’ is one such attempt to control your world to consecutively take over culture. Works of art displayed in public places are the magnets that may hold the public space together. They represent the relentless spiral of the energies of the people.”last_img read more

Kids Stay Free at select luxury Bahia properties

first_imgKids Stay Free at select luxury Bahia properties Friday, June 16, 2017 MIAMI — Bahia Principe Hotels & Resorts is making summer travel even more affordable for families with a Kids Stay Free offer at select properties.Available for stays through Oct. 31, the offer includes the new five-star Luxury Bahia Principe Fantasia Don Pablo Collection and Grand Bahia Principe Turquesa, where the first child stays free, as well as the Grand Bahia Principe Punta Cana where up to two kids stay free.“We have taken fantastic steps to make summer 2017 not only more kid-friendly than ever, but even more affordable as part of our commitment to offering all-inclusive luxury travel the whole family can enjoy,” said Helen Montijano, VP of Sales, USA. “From the new waterpark at Grand Bahia Principe Jamaica, to the new five-star Luxury Bahia Principe Fantasia Don Pablo Collection in the Dominican Republic, Bahia Principe knows how to turn family vacations into memorable Caribbean fairy tales – all while offering competitive rates.”More news:  ‘Turn around year’ for TPI brings double-digit growthThe newly-opened Luxury Bahia Principe Fantasia Don Pablo Collection in Punta Cana features a pool with a fairy tale castle, complete with its own moat and bridge, a delight for children of all ages. Other family-friendly features in the new Fantasia include entertainment for all ages and a Kids Club with costume workshops, arts and crafts activities, cooking classes, expeditions and a waterpark. The Fantasia Teens Club for guests aged 12 to 17 is equipped with a gym, movie theatre, DJ dance floor, video consoles, pool table, and spa.Bahia Principe hotels offer a wide array of kid-friendly touches, including family suites in select hotels where welcome packages include children’s bath kits and bathrobes, minibars that come with milkshakes and soft drinks, children’s mini-clubs and even kids spa treatments. Babysitting services let parents take a romantic break too. For guests looking for adventure, the Bahia Scouts program combines fun, learning and excitement in supervised activities split by age group.More news:  Sunwing offers ultimate package deal ahead of YXU flights to SNU, PUJBahia Principe Hotels & Resorts includes properties in the Dominican Republic, Mexico and Jamaica. Travelweek Group << Previous PostNext Post >>center_img Tags: Bahia Principe Hotels & Resorts Posted by Sharelast_img read more

Opening this December Melias newest resort in Punta Cana

first_img PALMA DE MALLORCA — Melia Hotels International is set to debut a sprawling new all-inclusive resort in Punta Cana in time for the busy winter season.Costing $110 million and featuring 288 suite-style accommodations, The Grand Reserve at Paradisus Palma Real is located 30 minutes from Punta Cana International Airport on the famed Playa de Bavaro. Upon completion, it will also boast seven restaurants and bars, a full-service spa, kids club, aqua adventure park and a wellness facility with gym equipment.Rooms will range from 800 to over 3,000 square feet, with suites including either one or two bedrooms, living and dining spaces, soaking tubs, walk-in showers, private balconies with hydro-massage whirlpool tubs and outdoor living spaces. Most noteworthy of the suites are The Grand Reserve’s Swim-Up Suites featuring one or two bedrooms, direct access to an exclusive pool, lush garden areas and a solarium.Co-existing with hotel guests will be an additional 144 suites for members of Circle by Melia for a total of 432 suites in the entire building. Launched in 2016, Circle by Melia is Melia Hotels International’s vacation membership program that includes private transfers, exclusive dining experiences, spa treatments and special add-on amenities for children and couples.More news:  Sunwing offers ultimate package deal ahead of YXU flights to SNU, PUJOther top selling points will be the Cigar Bar, coming this winter, The Grand Reserve Spa by Natura Bissé featuring 14 treatment rooms and a relaxation room, and Stay at One & Play at Three privileges, which include complete access to the extensive property offerings at both The Reserve and Paradisus Palma Real.“We’re eager and excited to welcome The Grand Reserve to the Melia Hotels International family later this year, said Alvaro Tejada, Senior Vice President for the Americas for Melia Hotels International.” With its unique design superior amenities and new technological advancements, The Grand Reserve is set to radically transform the way travelers experience our hotels in the Dominican Republic.”In addition to The Grand Reserve, Melia Hotels International is transforming its Meliá Caribe Tropical property into two distinct properties: Meliá Punta Cana Beach Resort for adults only, and Meliá Caribe Beach resort for families, set to be completed by November 2018. Share Thursday, June 21, 2018 Posted by Tags: Melia Hotels, Punta Canacenter_img Travelweek Group Opening this December: Melia’s newest resort in Punta Cana << Previous PostNext Post >>last_img read more

AE Networks Latin America has teamed up with Sony

first_imgA+E Networks Latin America has teamed up with Sony Pictures Television to launch the female-focused Lifetime channel in Latin America.A+E Networks Latin America, a joint venture between A+E Networks and Ole Communications, and Sony Pictures Television said they will launch Lifetime in Latin America and Brazil in July.The channel will feature scripted drama series, non-fiction series and movies.Scripted drama shows will include the premier of Witches of East End starring Julia Ormond and Mädchen Amick, the new season of Eva Longoria-produced Devious Maids and Drop Dead Diva with Brooke Elliott.Non-fiction shows will include Dance Moms, Bring It! and Abby’s Ultimate Dance Competition, while movies on the channel will include Steel Magnolias, Liz & Dick, Drew Peterson: Untouchable and Talhotblond.“We are thrilled to partner with Sony Pictures Television for the launch of Lifetime in Latin America and Brazil,” said Sean Cohan, executive vice-president, international, A+E Networks.“Lifetime and its content have an extremely loyal fan-base around the globe, and we are confident that it will develop an equally loyal audience in the Latin American region.”last_img read more

Switzerlandbased ADB will showcase a range of ove

first_imgSwitzerland-based ADB will showcase a range of over-the-top (OTT) solutions with regional solutions partner Vector at ANGA COM. ADB and Vector are working together to enable European service providers and operators to “maximise the cloud and deliver superior OTT video services across platforms and devices.”The pair are working together to help local operators launch personal TV services. ADB’s systems solutions deliver content to multi-platform environments and include features like start-over, catch-up TV and cloud DVR.“2015 is sure to be an explosive year for OTT. Consumer viewing habits are changing and more and more consumers are shifting from traditional TV viewing and turning to the smaller screen to watch their favourite content,” said ADB’s CEO, Peter Balchin.“OTT is a significant part of ADB´s software and solutions proposal. We have the right technology, expertise and delivery capability to help operators win and retain customers, and ultimately increase their return on investment.”ADB will demo its full OTT product suite at ANGA COM, including its GraphyneOTT application – a multi-DRM solution that lets OTT service providers upgrade to a live, linear broadcast service.ADB provides and integrates software, system and service solutions to cable, satellite, IPTV and broadband operators – including Swisscom, Telecom Italia, Telefonica, Telenet, and Vodafone. ADB and Vector will be exhibiting at ANGA COM at the Vector stand, hall 10.2, booth K15.last_img read more

Make sure you have a neutral setting Dont talk t

first_imgMake sure you have a neutral setting. Don’t talk to the child about liberty, obedience, or anything along those lines before asking the question. Make sure that you are feeling neutral too. You should want to know the child’s opinion, sincerely. If the child answers more than a simple ‘Yes’ or ‘No,’ write down precisely what they say. Then, if necessary, write down your interpretation of what the child said and why you interpreted their meaning that way. We’re all born knowing the truth, but by the time you’re four or five years old, they’ve beaten it out of you. – Attributed to Bob Dylan I think I’d be a bit more charitable than Mr. Dylan; I’d say that we’ve only had the truth partly beaten out of us by the age of five. I think truth endures in us, at least to a significant extent, up till puberty, after which it is beaten into submission over the next decade or so. The Crazy Years We all have experience with the tumultuous years that begin with puberty: First we are slapped with a rush of hormones. That triggers a reproductive imperative. That’s crazy-making enough, but then we find ourselves inside of a rigid, status-based system… a system that massively influences all of our potential mates. That’s a recipe for the corruption of thought, and it does corrupt our thoughts. Orson Welles was an unusually clear-thinking and experienced child… far more experienced than average. He spent his days (he was what we’d now call home schooled) reading the works of Shakespeare and all the existing Greek tragedies, repetitively. As a man, Orson was once interviewed about his young days. The interviewer asked what he had thought of teenagers. Orson replied, “I thought they were absolutely insane.” I think all of us can understand why. Getting to the Truth So, if we want to get a glimpse of human nature before it’s stressed and shaped during the crazy years, we should really go to pre-teens. Granted, kids are not the pure saints they are sometimes imagined to be… and it is true that these kids are already sexualized and trained in status these days… but there remains, in most of them, some residue of honest thinking. They have not yet been dragged all the way into the conformist way of mind. My hypothesis is that most of us are born as natural libertarians – having a built-in bias toward liberty. And I have a clean way of testing this idea: Go to pre-teens, in a neutral setting, and ask them a very simple question: Shouldn’t you be allowed to do anything you want, as long as you don’t hurt anyone? My guess is that the results would show a large majority agreeing with the statement, and the younger the respondent, the higher the percentage. A Challenge to You I’d like to propose we actually run such an experiment. I’ll be pleased to coordinate and publish the data. In order to ensure that the results are meaningful, I recommend the following: After you write down the answer, feel free to continue the discussion with the child if fitting, but not if there are other study participants in the area. Keep them neutral.    Can I ask you a question? I want to know what you think about this. Since children have notoriously short attention spans, ask the question only after you have calmed them and centered their attention. I suggest something like this: As I say, I’ll be pleased to tabulate and publish the results if one or more of our readers want to run the experiment. I think the results might be very interesting… and quite possibly very useful. Paul Rosenberg FreemansPerspective.comlast_img read more

Disabled campaigners have welcomed the longawaite

first_imgDisabled campaigners have welcomed the long-awaited publication of draft legislation to create Europe-wide access laws.The European Commission – the European Union’s executive body – finally published a European Accessibility Act this week, 15 years after promising to outlaw the discrimination faced by disabled people in accessing goods and services.It said the act would set “common accessibility requirements for certain key products and services”, including cashpoint machines and other banking services, personal computers, telephones and television equipment, telephony and audio-visual services, transport, e-books and e-commerce.The publication came the day before the UN’s International Day of Persons with Disabilities (3 December), which this year had a theme of “access and empowerment for people of all abilities”.The proposed European Accessibility Act would complement Britain’s own Equality Act by making existing voluntary European access standards mandatory across the European Union (EU).The act’s publication comes only two months after the United Nations said it was “concerned” that a European Accessibility Act had not yet been adopted by the EU, and gave it just 12 months to explain how it would be introduced.Yannis Vardakastanis (pictured), president of the European Disability Forum (EDF), said the act could “contribute to the empowerment of persons with disabilities to better enjoy the freedom of movement of persons, goods and services in the European single market”.He said the act had been a “top priority” for EDF and its members for many years, through its Freedom of Movement campaign.But he said it was too early to comment on the content of the act itself.He said: “In the coming weeks and months EDF and its members will work together with the EU institutions, partner organisations and other stakeholders to make this piece of legislation meaningful for 80 million people with disabilities in Europe.”The European Blind Union (EBU) also welcomed the act’s publication.Wolfgang Angermann, EBU’s president, said: “We have faced discrimination for long enough.“Along with our partners in the European Disability Forum, we will respond thoughtfully to the consultation which has just opened on this proposed legislation.“After that, we will be urging all those involved in the legislative process to ensure this new law is fully effective and thorough.”Marianne Thyssen, the EU’s commissioner for employment, social affairs, skills and labour mobility, said: “Disability should not be a barrier to full participation in society, nor should the lack of EU common rules be a barrier to cross-border trade in accessible products and services.“With this act, we want to deepen the internal market and use its potential for the benefit of both companies and citizens with disabilities. In fact, we all may benefit from it.”The commission believes the act will make it easier for companies that want to export goods and services within the EU, and will help small business “take full advantage of the EU market”, with disabled people benefiting from “a greater supply of accessible products and services at more competitive prices”.Without the act, each EU country would continue to develop different laws as they implemented their accessibility obligations under the UN Convention on the Rights of Persons with Disabilities.Richard Howitt, the Labour MEP and co-president of the European Parliament’s all-party disability rights group, said European officials had “shamefully dragged their feet” on a promise made 15 years ago to outlaw disability discrimination in access to goods and services.  Howitt, who played a key role in negotiating that promise in 2000, said it would have been long-forgotten if it had not been for “16 years of relentless campaigning by disabled people’s organisations”.Howitt said: “It is shameful how long disabled people have been forced to wait and the foot-dragging by anyone and everyone in Brussels has to stop right now.“Echoing the slogans of disability activists, this is much more a victory by rather than for disabled people themselves.“When I helped negotiate the EU law against disability discrimination in access to employment in 2000, the European Parliament was promised that action to outlaw the same discrimination in access to goods and services would soon follow.“Today, we are close to achieving what for many years has simply only been a dream and equality itself is finally being given equal treatment.”He added: “Although I am proud that Europe has made progress in the past on disability access rules in relation to the installation of lifts, for some public transport and on the internet, the bitter truth is that a large swathe of the built environment remains a ‘no go’ area for people with disabilities in Britain and in Europe.”There will now be a period of eight weeks’ consultation, followed by legislative procedures in the European Parliament and the Council of the European Union.last_img read more

Autism is not curable not even by prayer – Autism Advisory Council

first_img <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=ab2c8853&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=97&amp;cb={random}&amp;n=ab2c8853&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a> SharePrint Autism cannot be cured, not even by prayer, the Autism Advisory Council has said.Their comments come in response to the broadcast of a television programme on F-Living in which the story of an autistic child is said to be ‘cured of autism’ through prayers.AAC responds that ‘there is nothing to be cured as regards autism.’‘Autism is not a disease. It is a lifelong neurological difference, and while certain behaviours and co-occurring conditions – such as anxiety – are regularly linked to it, autism itself is part and parcel of a person’s identity, and not something to be ‘grown’/ ‘prayed’ out of,’ they add.AAC’s concerns are raised after the Il-Verita programme on F-Living broadcast an interview with Ms Phyllisienne Brincat who alleged that prayer would help cure a child’s Autism. This interview was complemented by a video clip which is understood to have dated back to 2013.They stress that this programme had misrepresented understandings of how to treat autism and does, ‘a great disservice to persons on the autism spectrum and their family members.’To conclude, the body calls on the Broadcasting Authority to act on creating better representation of disability on its board.Get Your Facts rightIn addition to the Autism Advisory Council’s response to the misrepresentation of Autism and its apparent cure through prayer, the Autism Parents Association has urged the producers of the F-Living programme il-Verita, to ‘get your facts right.’The association states that the programme had disseminated ‘wrong information’ that insulted the body and parents with children who are Autistic.‘No one who permitted such a programme to be aire has a glimpse or a clue on what is the real definition of Autism and all the hardships which parents go through when their children are diagnosed,’ they add.While requesting the programme apologises to the families who they offended, they also state that they should refer to the evidence and expertise on the subject ‘before reaching out to viewers ‘publicly’ and not refer to unverified and outdated video footage.’WhatsApplast_img read more

Jeff Bezos Did What The Week In Entrepreneur News Quiz

first_img Register Now » Learn how to successfully navigate family business dynamics and build businesses that excel. Quizzes Add to Queue –shares Entrepreneur Staff How plugged in are you? Find out! September 14, 2018 Entrepreneur Staff Free Webinar | July 31: Secrets to Running a Successful Family Business 1 min read This week, Tesla got a jump start (of sorts) and a little girl’s crunchy dream came true. Were you paying attention to the goings on in the entrepreneurial universe? See how plugged in you were to this week’s news hits.Related: Are You a Genius? Take This Quiz and Find Out!Close Image credit: Bloomberg | Getty Images Next Article Jeff Bezos Did What?! The Week In Entrepreneur News Quizlast_img read more

Could US Tech Companies Face Overseas Warrants

first_img –shares Image credit: Peopleimages | Getty Images The Obama administration is said to be in negotiations with international governments that could eventually allow them to serve U.S. technology companies with warrants on things like email and wiretaps, the Wall Street Journal reports.The first agreement will likely be signed with the U.K., according to the report. The negotiations were discussed by a senior Justice Department official on Friday. Any deals would not provide access to data from U.S. citizens or residents. They would also have to be approved by Congress and international lawmakers.Complicating matters is a recent federal appeals court ruling that said U.S.-based federal warrants cannot be used on search data stored in overseas data centers. The case, brought by Microsoft, was viewed as a major blow to law enforcement and a win for privacy advocates.Law enforcement argues it should have access to data in the event it can stop or solve a crime. Particularly in the wake of the Snowden leaks, however, technology companies do not want customers to think they are participating in government surveillance.The move to allow foreign governments to access U.S. Internet company data could make that divide even greater. Privacy advocates aware of the negotiations are already decrying the proposals, saying that it would put individual liberty at risk.Looking ahead, any U.K. deal would serve as a template, the Journal says. But Congress has dragged its feet on updates to legislation like the Electronic Communications Privacy Act (ECPA), which dates back to 1986. July 19, 2016 Add to Queue Next Article 2 min read International Business Don Reisinger 2019 Entrepreneur 360 List Apply Now » This story originally appeared on PCMag Could U.S. Tech Companies Face Overseas Warrants? Contributing Writer The only list that measures privately-held company performance across multiple dimensions—not just revenue.last_img read more

New findings bring about better understanding of many cancers metabolic needs

first_img Source:https://stemcell.ucla.edu/news/ucla-study-overturns-dogma-cancer-metabolism-theory-%E2%80%93-tumors-not-addicted-glucose-previously Reviewed by James Ives, M.Psych. (Editor)Jan 10 2019Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism.The findings could bring about a better understanding of many cancers’ metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.The research, led by senior authors Heather Christofk and Bill Lowry, was published in the journal Nature Communications.A fundamental doctrine of cancer metabolism theory is that cancer cells are glycolytic, meaning they consume more glucose and produce more lactate than normal cells. This metabolic shift, called aerobic glycolysis, or the Warburg effect, has been observed in thousands of experiments and inspired treatments that aim to stop tumor growth by preventing cancer cells from increasing their glucose consumption. To date, this treatment approach has not proven successful in clinical trials.Considering these clinical limitations, Christofk and Lowry set out to examine if increased glucose consumption is truly indispensable to cancer formation and growth.They decided to approach this problem using squamous cell skin cancer as a model, as they had made two key discoveries about the nature of this cancer in recent years.In 2011, they determined that squamous cell skin cancer, which forms in the thin, flat cells found on the surface of the skin – can originate from hair follicle stem cells. Hair follicle stem cells produce hair throughout a person’s lifetime and remain mostly inactive, but spring to action during a new hair cycle, which is when new hair growth occurs. In 2017, the pair found that hair follicle stem cells are glycolytic and ramp up their glucose consumption to quickly activate and produce hair follicles.”These findings led us to question: Are squamous cell skin cancer cells glycolytic because they are cancer cells that altered their metabolism to fuel their rapid growth, or because the cells they originated from – hair follicle stem cells – were glycolytic?” said Lowry, a professor of molecular, cell and developmental biology.To answer this question, the team studied the progression of squamous cell skin cancer in animal models whose hair follicle stem cells had been genetically modified to limit their glucose consumption. Specifically, they de-activated a gene called lactate dehydrogenase-a, which catalyzes the final step in a cell’s process of converting glucose to lactate. Deactivating this gene prevented this final step from taking place, which in turn caused the cells to dramatically reduce their glucose consumption.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsUsing machine learning algorithm to accurately diagnose breast cancerThe change had no effect on cancer incidence or progression. When faced with insufficient glucose for their increased needs, the cancer cells in this model simply altered their metabolism to derive energy from the amino acid glutamine.”These findings suggest that tumors are metabolically flexible and can use nutrients other than glucose to fuel growth,” said Christofk, an associate professor of biological chemistry and molecular and medical pharmacology. “Understanding all of the nutrients cancers use for growth is critical to developing drugs that can successfully target cancer’s metabolism.”The team double-checked their findings by conducting a converse experiment using hair follicle stem cells that had been genetically modified to increase glucose consumption. If their initial finding was incorrect, stimulating glucose consumption would make the tumors grow faster – it did not.”The cells still formed cancer, but they didn’t do so any faster and it wasn’t any more serious,” said Aimee Flores, a postdoctoral fellow in Lowry’s lab and a first author of the study. “The behavior and progression of the disease was quite similar to the disease observed in the model with reduced glucose consumption.”As a next step, the team will conduct experiments to determine if reducing the consumption of both glucose and glutamine can stop the growth of squamous cell skin cancers.”If limiting cancer’s intake of both of these nutrients is shown to be effective, then that points to a path toward the clinic in the form of a combination therapy,” said Lowry.There is already some evidence that a combination therapy of this kind could treat squamous cell lung cancer. David Shackelford, an associate professor in the division of pulmonary and critical care medicine and a colleague of Christofk and Lowry’s at the UCLA Jonsson Comprehensive Cancer Center, found that squamous cell lung cancers metabolize glutamine when unable to increase their glucose consumption.Shackelford and his collaborators – including Christofk –  also identified two drug candidatesthat, when used in combination, may stop the growth of squamous cell lung cancers by reducing the uptake of both of these nutrients.Despite these encouraging findings, the road to bringing combination therapies for squamous cell cancers to humans is a long one, cautioned Lowry. “Every drug you add to a potential treatment carries its own risks and side effects, so identifying and testing combination therapies that will be both safe and effective in humans is a long and arduous process,” he said.last_img read more

New study evaluates complexity of patients undergoing headCT examinations

first_img“Head-CT is not only most frequently ordered in the ED, but also during the most complex ED visits, suggesting that the ICD-10 codes associated with such exams do not appropriately reflect patient complexity,” stated coauthor Ryan Lee, M.D., a radiologist at Einstein Healthcare Network, “The valuation process should also consider the complexity of associated billed patient encounters.”Source: Harvey L. Neiman Health Policy Institute Of the 6,363,404 head-CT exams in 2017, 56.1% were performed in the ED and 70% of non-contrast exams performed in the ED were ordered in the most complex patient encounters (level 5 visits). The most common diagnosis reported for head-CT scans without contrast agents in level 5 visits were “dizziness and giddiness”, and for head-CT without and with contrast agents was “headache”.”Melissa M. Chen, MD, Lead Author, Clinical Neuroradiologist, University of Texas MD Anderson Cancer Center Reviewed by James Ives, M.Psych. (Editor)May 20 2019Computed tomography (CT) of the head uses special X-ray equipment to help assess head injuries, dizziness, and other symptoms of the brain. This new study, published online in Current Problems in Diagnostic Radiology, evaluates the complexity of patients undergoing head-CT examinations.Chen and her co-investigators used 2017 Medicare claims data to identify the most common site for performing head-CT examinations. After finding the most common site was emergency departments (ED), the authors classified the data by the complexity of the patient’s ED visit. The visits were analyzed by the level of complexity (1-least complex to 5-most complex patient) as well as the diagnosis reported on the billed head CT claims.last_img read more

Phishing success linked to incentives and sticking to an effective strategy

Credit: CC0 Public Domain Citation: Phishing success linked to incentives and sticking to an effective strategy (2018, February 21) retrieved 18 July 2019 from https://phys.org/news/2018-02-phishing-success-linked-incentives-effective.html Not all phishing campaigns work, but when an attacker perseveres with a strategy that does it is the key to their success. That’s the finding of a new study focusing on the attacker, a largely ignored but crucial aspect of phishing. In addition to identifying successful strategies, it also reveals that attackers are motivated by quicker and larger rewards—with creative individuals putting more effort into constructing these malicious emails. Insights from the study, published today in open-access journal Frontiers in Psychology, can be used to develop tools and training procedures to detect phishing emails. Provided by Frontiers Gone phishin’: CyLab exposes how our ability to spot phishing emails is far from perfect “We find specific phishing strategies, such as the use of authoritative tone, expressing shared interest and sending notifications, are more likely to succeed,” says Dr. Prashanth Rajivan, lead author of the study and based at Carnegie Mellon University, Pennsylvania, USA.Phishing is a common form of cyber-attack. Criminals impersonate a trustworthy third party to persuade people to visit fraudulent web sites or download malicious attachments, with the intent of compromising their security. While research has largely focused on the victims of these crimes, this new study looks at a critical aspect of phishing: the attacker’s behavior and strategies.”We created a game-like experiment to assess how well different strategies work, and to understand how incentives and success rates, or an individual’s creativity, can affect motivation,” explains Dr. Rajivan.In the experiment, human participants play the role of a phishing attacker and accumulate points, over a number turns, for successfully deceiving other people who are the ‘end-user’ performing an email management task. The game was carefully constructed to train and reward people into producing phishing emails that employ different strategies and topics.Strategies that were less likely to succeed included ‘offering deals,’ ‘selling illegal materials’ and ‘using a positive tone.'”People may be less receptive to strategies associated with scams that worked a decade ago,” explains Dr. Rajivan. “More successful strategies today would be ‘sending notifications,’ ‘use of authoritative tone,’ ‘taking advantage of trust by impersonating a friend or expressing shared interest,’ and ‘communicating failure’.”The repeated design of the game allowed the researchers to assess the attacker’s tactics over time. This revealed that perseverance with a successful strategy, rather than switching from one to another, can yield better results. The researchers attribute this to the attackers improving the email text at each turn.Incentives had a direct influence on motivation, with delayed rewards resulting in lesser effort. The easier and sooner high rewards were gained, the more effort an attacker applied to designing persuasive emails, as did individuals who scored high in a ‘creativity’ test. There was no evidence to suggest, however, that creativity could be used as a predictor of phishing success.”There has been a resurgence in phishing attacks in recent years and the regular, non-expert users of the Internet are usually the victims of these crimes. We need to improve current security practices to change the incentive structure for the attacker. If the rewards are greater than the costs, attackers will continue to exert more effort into phishing campaigns,” says Dr. Rajivan. “We think that attackers with higher creativity may be capable of changing and adapting emails to evade detection, even though their creativity cannot determine how much success they achieve in getting the end-user to respond.”He continues, “Our novel experimental design could be used to crowdsource people to play our game, which would give us lots of information on phishing success rates and how these emails can be adapted, thereby improving detection software. In addition, we could use it as a training tool to help people think like hackers to better detect phishing emails.” Journal information: Frontiers in Psychology Explore further More information: Frontiers in Psychology (2018). DOI: 10.3389/fpsyg.2018.00135 , https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00135/full This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Chandrababu Naidu protests poll panels unilateral decisions

first_img COMMENT ‘EC taking orders from Modi govt’ COMMENTS SHARE Published on Chandrababu Naidu Andhra Pradeshcenter_img national elections SHARE SHARE EMAIL Elections 2019 On the eve of the Lok Sabha and Assembly elections in the State, Andhra Pradesh Chief Minister and Telugu Desam Party President N Chandrababu Naidu on Wednesday lodged a protest with the Chief Electoral Officer, Gopalakrishna Dwivedi, objecting to what he called “the unilateral decisions taken by the Election Commission on complaints lodged by the YSR Congress Party leaders.”He met Dwivedi along with his party leaders to submit the complaint and then spoke to the media. “We have registered our objections in the letter, and orally explained our position very respectfully to the officer, and requested him to conduct the elections in a free, fair and impartial manner,” he said.Arbitrary transfersNaidu said there should be a level playing field and the Election Commission (EC) should not act in an arbitrary manner and take unilateral decisions. “Several IAS and IPS officers were transferred and relieved of election duties, based on false and frivolous complaints lodged by YSR Congress leaders. Even the Chief Secretary was transferred. The District Collector of Srikakulam was transferred even before the election code came into force. How can such actions be justified or defended? The autonomy of the institution comes into question if such actions are taken. Under PM Modi, the credibility of all institutions is eroded,” he said.He also said a series of raids by the Income Tax Department officials in the State were going on at the houses and companies of Telugu Desam party leaders. “It is utterly undemocratic and against the guidelines of the Supreme Court. Such high-handedness has never been witnessed in the country before. Democracy is in danger. We have to save the nation, save democracy,” he said.He said a letter was submitted by 66 highly-respected former bureaucrats to the President against EC’s style of functioning. “The Modi government is utterly unresponsive and undemocratic. I appeal to all democratic forces in the country to join hands and save our great State and the nation,” he said.   April 10, 2019last_img read more

Exclusive Pentagon races to track US rare earths output amid China trade

first_img World 29 May 2019 China ready to hit back at U.S. with rare earths – newspapers Markets 15h ago Most Asean markets fall on weak China data; Singapore edges up World 14h ago China says U.S. should ‘not play with fire’ on Taiwan (Reuters) – The Pentagon is rapidly assessing the United States’ rare earths capability in a race to secure stable supply of the specialized material amid the country’s trade conflict with China, which controls the rare earths industry, according to a government document seen by Reuters. The push comes weeks after China threatened to curb exports to the United States of rare earths, a group of 17 minerals used to build fighter jets, tanks and a range of consumer electronics. The Pentagon wants miners to describe plans to develop U.S. rare earths mines and processing facilities, and asked manufacturers to detail their needs for the minerals, according to the document, which is dated June 27.Responses are required by July 31, a short time frame that underscores the Pentagon’s urgency. The U.S. government’s fiscal year ends in September. AdChoices广告The U.S. Air Force, which is part of the Pentagon and created the document, confirmed the document’s existence. The Pentagon’s headquarters did not respond to a request for comment. The responses will be reviewed by two government contractors, including Northrop Grumman Corp, which did not respond to requests for comment.”The government wants to know how much of these minerals we could eventually be producing, and how soon,” said Anthony Marchese, chairman of Texas Mineral Resources Corp, which is working to develop the Round Top rare earth deposit in the state’s western edge.Several miners, though, declined to comment when asked if they will reply to the Pentagon, a sign of the sensitivity around rare earth mine development during the ongoing U.S.-China trade dispute.The document does not directly promise loans, grants or other financial support to U.S. rare earths projects. But the Pentagon’s request is derived in part from the Defense Production Act (DPA), a 1950s-era U.S. law that gives the Pentagon wide berth to procure equipment necessary for the national defence. Some type of financial assistance is ultimately expected for the industry after the Pentagon reviews the responses, according to industry analysts and consultants.CHINA DOMINATESAlthough China contains only a third of the world’s rare earth reserves, it accounts for 80% of U.S. imports of minerals because it controls nearly all of the facilities to process the material, according to U.S. Geological Survey data.It is unclear how much money the U.S. military will spend to boost America’s rare earths industry as the DPA does not set a financial limit. The June Pentagon letter notes that government investments usually range from $5 million (£3.9 million) to $20 million per project.”The overall goal is to secure and assure a viable, domestic supplier (of rare earths) for the long-term,” according to the nine-page document.The Air Force Research Laboratory, which drafted the request, said it wants information related to U.S. rare earth “shortcomings, risks, and opportunities which may be addressed by investments” by the military.”There is no guarantee that any submitted topic will” receive military support, Diana Carlin, the Air Force’s executive agent program manager for the DPA program related to procurement, said in an emailed statement to Reuters. James Litinsky, co-chairman of MP Materials, which owns the Mountain Pass mine in California, said the United States needs “a sustainable supermajor for the Western supply of these minerals.” A supermajor would be a large producer that dominates the global industry. MP Materials, the only existing U.S. rare earths facility, ships its ore to China for processing and has been subject to a 25% tariff since last month.Some industry analysts have called for the Pentagon to broaden the scope of its study and commit to direct government funding of rare earth magnet and motor manufacturing, much like China’s government.”The U.S. government doesn’t have a holistic approach to the entire rare earths supply chain, even now, and that’s a problem,” Jack Lifton, an industry analyst with Technology Metals Research LLC, said in an interview this week.BILLS IN U.S. SENATEThe Pentagon’s request builds on several executive orders from President Donald Trump on strategic minerals, which he has said are critical for national defence.Several U.S. senators have sponsored legislation in recent weeks designed to boost domestic production of lithium, rare earths and other strategic minerals. On Thursday, U.S. Senator Marco Rubio, a Florida Republican, introduced a bill that would let rare earths producers form cooperatives, avoiding U.S. antitrust statutes.None of the bills have passed yet.The Pentagon has also held talks with rare earths suppliers in Malawi and Burundi, department officials told Reuters last month.”There’s a heightened sense of urgency on developing a rare earth supply chain in North America,” said Don Lay, chief executive of Medallion Resources Ltd, which earlier this month said it was studying potential sites across North America to develop an extraction plant for rare earths.(For a graphic on ‘Rare earth export prices perk up after China rattles trade war sabre’, click https://tmsnrt.rs/2Id5tQ2)(For an interactive graphic on ‘Rare earth production’, click https://tmsnrt.rs/2I9MfL5) (Reporting by Ernest Scheyder in Houston; Additional reporting by Mike Stone in Washington; Editing by Amran Abocar and Matthew Lewis) Related News Related News {{category}} {{time}} {{title}}last_img read more